![]() Furthermore, modern computers now have multiple cores and these have been exploited to extend the range and speed of the Coot tools. 1, 2 The same principles were applicable to model building and refinement of cryo‐EM maps, 3 and tools in Coot have now been expanded to assist building of large macromolecular assemblies into such maps. ![]() Originally, Coot was designed for interpretation of MX data, the focus being tools for moving and refining one or a small number of residues, or ligands. ![]() Coot is an interactive molecular graphics desktop application that provides an environment where model building and refinement can be used together with validation. Model building is an essential step in structural biology that facilitates interpretation of structural data obtained by different methods, including macromolecular crystallography (MX) and electron cryomicroscopy (cryo‐EM).
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